학술논문
Exposure of Egyptian Rousette Bats (Rousettus aegyptiacus) and a Little Free-Tailed Bat (Chaerephon pumilus) to Alphaviruses in Uganda
Document Type
article
Author
Rebekah C. Kading; Erin M. Borland; Eric C. Mossel; Teddy Nakayiki; Betty Nalikka; Jeremy P. Ledermann; Mary B. Crabtree; Nicholas A. Panella; Luke Nyakarahuka; Amy T. Gilbert; Julian C. Kerbis-Peterhans; Jonathan S. Towner; Brian R. Amman; Tara K. Sealy; Barry R. Miller; Julius J. Lutwama; Robert M. Kityo; Ann M. Powers
Source
Diseases, Vol 10, Iss 4, p 121 (2022)
Subject
Language
English
ISSN
2079-9721
Abstract
The reservoir for zoonotic o’nyong-nyong virus (ONNV) has remained unknown since this virus was first recognized in Uganda in 1959. Building on existing evidence for mosquito blood-feeding on various frugivorous bat species in Uganda, and seroprevalence for arboviruses among bats in Uganda, we sought to assess if serum samples collected from bats in Uganda demonstrated evidence of exposure to ONNV or the closely related zoonotic chikungunya virus (CHIKV). In total, 652 serum samples collected from six bat species were tested by plaque reduction neutralization test (PRNT) for neutralizing antibodies against ONNV and CHIKV. Forty out of 303 (13.2%) Egyptian rousettes from Maramagambo Forest and 1/13 (8%) little free-tailed bats from Banga Nakiwogo, Entebbe contained neutralizing antibodies against ONNV. In addition, 2/303 (0.7%) of these Egyptian rousettes contained neutralizing antibodies to CHIKV, and 8/303 (2.6%) contained neutralizing antibodies that were nonspecifically reactive to alphaviruses. These data support the interepidemic circulation of ONNV and CHIKV in Uganda, although Egyptian rousette bats are unlikely to serve as reservoirs for these viruses given the inconsistent occurrence of antibody-positive bats.