학술논문
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
Document Type
article
Source
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Runxiang Qiu et al find that conditional knockout of Kif20a, a regulator of cytokinesis and neural progenitor cell fate, induces early cell cycle exit and precocious neuronal differentiation of cerebellar granule neuron progenitors. They show that Kif20a depletion suppresses tumour formation in genetic and xenograft mouse models of medulloblastoma, indicating the value of targeting daughter cell fate specification.