학술논문
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
Document Type
article
Author
Kathryn A. Ryan; Kevin R. Bewley; Susan A. Fotheringham; Gillian S. Slack; Phillip Brown; Yper Hall; Nadina I. Wand; Anthony C. Marriott; Breeze E. Cavell; Julia A. Tree; Lauren Allen; Marilyn J. Aram; Thomas J. Bean; Emily Brunt; Karen R. Buttigieg; Daniel P. Carter; Rebecca Cobb; Naomi S. Coombes; Steve J. Findlay-Wilson; Kerry J. Godwin; Karen E. Gooch; Jade Gouriet; Rachel Halkerston; Debbie J. Harris; Thomas H. Hender; Holly E. Humphries; Laura Hunter; Catherine M. K. Ho; Chelsea L. Kennard; Stephanie Leung; Stephanie Longet; Didier Ngabo; Karen L. Osman; Jemma Paterson; Elizabeth J. Penn; Steven T. Pullan; Emma Rayner; Oliver Skinner; Kimberley Steeds; Irene Taylor; Tom Tipton; Stephen Thomas; Carrie Turner; Robert J. Watson; Nathan R. Wiblin; Sue Charlton; Bassam Hallis; Julian A. Hiscox; Simon Funnell; Mike J. Dennis; Catherine J. Whittaker; Michael G. Catton; Julian Druce; Francisco J. Salguero; Miles W. Carroll
Source
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
SARS-CoV-2 induces mild infection in ferret model. Here, Ryan et al. characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shedding, and pathology in ferrets and finally provide evidence for protection after re-challenge.