학술논문
Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 -December 2021.
Document Type
article
Author
Sana Mahtab; Shabir A Madhi; Vicky L Baillie; Toyah Els; Bukiwe Nana Thwala; Dickens Onyango; Beth A Tippet-Barr; Victor Akelo; Kitiezo Aggrey Igunza; Richard Omore; Shams El Arifeen; Emily S Gurley; Muntasir Alam; Atique Iqbal Chowdhury; Afruna Rahman; Quique Bassat; Inacio Mandomando; Sara Ajanovic; Antonio Sitoe; Rosauro Varo; Samba O Sow; Karen L Kotloff; Henry Badji; Milagritos D Tapia; Cheick B Traore; Ikechukwu U Ogbuanu; James Bunn; Ronita Luke; Sulaiman Sannoh; Alim Swarray-Deen; Nega Assefa; J Anthony G Scott; Lola Madrid; Dadi Marami; Surafel Fentaw; Maureen H Diaz; Roosecelis B Martines; Robert F Breiman; Zachary J Madewell; Dianna M Blau; Cynthia G Whitney; CHAMPS Consortium
Source
PLOS Global Public Health, Vol 3, Iss 3, p e0001612 (2023)
Subject
Language
English
ISSN
2767-3375
Abstract
Each year, 2.4 million children die within their first month of life. Child Health and Mortality Prevention Surveillance (CHAMPS) established in 7 countries aims to generate accurate data on why such deaths occur and inform prevention strategies. Neonatal deaths that occurred between December 2016 and December 2021 were investigated with MITS within 24-72 hours of death. Testing included blood, cerebrospinal fluid and lung cultures, multi-pathogen PCR on blood, CSF, nasopharyngeal swabs and lung tissue, and histopathology examination of lung, liver and brain. Data collection included clinical record review and family interview using standardized verbal autopsy. The full set of data was reviewed by local experts using a standardized process (Determination of Cause of Death) to identify all relevant conditions leading to death (causal chain), per WHO recommendations. For analysis we stratified neonatal death into 24-hours of birth, early (1-