학술논문
Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants
Document Type
article
Author
James Logue; Robert M. Johnson; Nita Patel; Bin Zhou; Sonia Maciejewski; Bryant Foreman; Haixia Zhou; Alyse D. Portnoff; Jing-Hui Tian; Asma Rehman; Marisa E. McGrath; Robert E. Haupt; Stuart M. Weston; Lauren Baracco; Holly Hammond; Mimi Guebre-Xabier; Carly Dillen; M. Madhangi; Ann M. Greene; Michael J. Massare; Greg M. Glenn; Gale Smith; Matthew B. Frieman
Source
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Current SARS-CoV-2 variants evade immune responses induced by approved vaccines. In this study, the authors find that a recombinant prefusion-stabilized Beta spike protein vaccine confers broad neutralization capacity in mice and non-human primates as well as protective antibody and immune memory responses.