학술논문
TNF-related apoptosis-inducing ligand, interferon gamma-induced protein 10, and C-reactive protein in predicting the progression of SARS-CoV-2 infection: a prospective cohort study
Document Type
article
Author
Sina A. Tegethoff; Guy Danziger; Dennis Kühn; Charlotte Kimmer; Thomas Adams; Lena Heintz; Carlos Metz; Katharina Reifenrath; Rebecca Angresius; Sebastian Mang; Torben Rixecker; André Becker; Jürgen Geisel; Christophe Jentgen; Frederik Seiler; Matthias C. Reichert; Franziska Fröhlich; Sascha Meyer; Jürgen Rissland; Sebastian Ewen; Gudrun Wagenpfeil; Katharina Last; Sigrun Smola; Robert Bals; Frank Lammert; Sören L. Becker; Marcin Krawczyk; Philipp M. Lepper; Cihan Papan
Source
International Journal of Infectious Diseases, Vol 122, Iss , Pp 178-187 (2022)
Subject
Language
English
ISSN
1201-9712
Abstract
ABSTRACT: Background: Early prognostication of COVID-19 severity will potentially improve patient care. Biomarkers, such as TNF-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein 10 (IP-10), and C-reactive protein (CRP), might represent possible tools for point-of-care testing and severity prediction. Methods: In this prospective cohort study, we analyzed serum levels of TRAIL, IP-10, and CRP in patients with COVID-19, compared them with control subjects, and investigated the association with disease severity. Results: A total of 899 measurements were performed in 132 patients (mean age 64 years, 40.2% females). Among patients with COVID-19, TRAIL levels were lower (49.5 vs 87 pg/ml, P = 0.0142), whereas IP-10 and CRP showed higher levels (667.5 vs 127 pg/ml, P