학술논문
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Document Type
article
Author
Sílvia Bonàs-Guarch; Marta Guindo-Martínez; Irene Miguel-Escalada; Niels Grarup; David Sebastian; Elias Rodriguez-Fos; Friman Sánchez; Mercè Planas-Fèlix; Paula Cortes-Sánchez; Santi González; Pascal Timshel; Tune H. Pers; Claire C. Morgan; Ignasi Moran; Goutham Atla; Juan R. González; Montserrat Puiggros; Jonathan Martí; Ehm A. Andersson; Carlos Díaz; Rosa M. Badia; Miriam Udler; Aaron Leong; Varindepal Kaur; Jason Flannick; Torben Jørgensen; Allan Linneberg; Marit E. Jørgensen; Daniel R. Witte; Cramer Christensen; Ivan Brandslund; Emil V. Appel; Robert A. Scott; Jian’an Luan; Claudia Langenberg; Nicholas J. Wareham; Oluf Pedersen; Antonio Zorzano; Jose C Florez; Torben Hansen; Jorge Ferrer; Josep Maria Mercader; David Torrents
Source
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Genome-wide association studies have uncovered several loci associated with diabetes risk. Here, the authors reanalyse public type 2 diabetes GWAS data to fine map 50 known loci and identify seven new ones, including one near ATGR2 on the X-chromosome that doubles the risk of diabetes in men.