학술논문
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance
Document Type
article
Author
Laura Ramos Garcia; Tencho Tenev; Richard Newman; Rachel O. Haich; Gianmaria Liccardi; Sidonie Wicky John; Alessandro Annibaldi; Lu Yu; Mercedes Pardo; Samuel N. Young; Cheree Fitzgibbon; Winnie Fernando; Naomi Guppy; Hyojin Kim; Lung-Yu Liang; Isabelle S. Lucet; Andrew Kueh; Ioannis Roxanis; Patrycja Gazinska; Martin Sims; Tomoko Smyth; George Ward; John Bertin; Allison M. Beal; Brad Geddes; Jyoti S. Choudhary; James M. Murphy; K. Aurelia Ball; Jason W. Upton; Pascal Meier
Source
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Necroptosis is a form of cell death characterized by membrane rupture via MLKL oligomerization, although mechanistic details remain unclear. Here, the authors show that MLKL ubiquitylation of K219 facilitates high-order membrane assembly and subsequent rupture, promoting cytotoxicity.