학술논문
Leptin gene variants and colorectal cancer risk: Sex-specific associations.
Document Type
article
Author
Kelsey A Chun; Jonathan M Kocarnik; Sheetal S Hardikar; Jamaica R Robinson; Sonja I Berndt; Andrew T Chan; Jane C Figueiredo; Noralane M Lindor; Mingyang Song; Robert E Schoen; Richard B Hayes; John D Potter; Rami Nassir; Stéphane Bézieau; Loic Le Marchand; Martha L Slattery; Emily White; Ulrike Peters; Polly A Newcomb
Source
PLoS ONE, Vol 13, Iss 10, p e0206519 (2018)
Subject
Language
English
ISSN
1932-6203
Abstract
BACKGROUND:High levels of serum leptin and low levels of serum adiponectin are strongly correlated with obesity, a well-established risk factor for colorectal cancer (CRC). Growing evidence suggests that dysregulation of leptin and adiponectin levels may play an etiological role in colorectal carcinogenesis. We evaluated 20 candidate variants in 4 genes previously shown to alter serum leptin and adiponectin levels for associations with obesity (BMI>30 kg/m2) and CRC risk. METHODS:We analyzed 6,246 CRC cases and 7,714 population-based controls from 11 studies within the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Associations of each variant with obesity or CRC were evaluated using multivariate logistic regression models stratified by sex and adjusted for age, a study variable, and the first three principal components of genetic ancestry. Gene-specific False Discovery Rate (FDR)-adjusted p-values