학술논문
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia
Document Type
article
Author
Nadia El Khawanky; Amy Hughes; Wenbo Yu; Renier Myburgh; Tony Matschulla; Sanaz Taromi; Konrad Aumann; Jade Clarson; Janaki Manoja Vinnakota; Khalid Shoumariyeh; Cornelius Miething; Angel F. Lopez; Michael P. Brown; Justus Duyster; Lutz Hein; Markus G. Manz; Timothy P. Hughes; Deborah L. White; Agnes S. M. Yong; Robert Zeiser
Source
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The success of CAR-T cells for treating acute myeloid leukaemia (AML) is hampered by toxicity to normal cells and low CAR-T cell persistence. Here, the authors show that the demethylating compound 5′-Azacitdine increases anti-CD123 CAR-T cell cytotoxicity against AML.