학술논문
Combined obstructive airflow limitation associated with interstitial lung diseases (O-ILD): the bad phenotype ?
Document Type
article
Author
Source
Respiratory Research, Vol 23, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
1465-993X
Abstract
Abstract Background Patients suffering from combined obstructive and interstitial lung disease (O-ILD) represent a pathological entity which still has to be well clinically described. The aim of this descriptive and explorative study was to describe the phenotype and functional characteristics of a cohort of patients suffering from functional obstruction in a population of ILD patients in order to raise the need of dedicated prospective observational studies and the evaluation of the impact of anti-fibrotic therapies. Methods The current authors conducted a retrospective study including 557 ILD patients, with either obstructive (O-ILD, n = 82) or non-obstructive (non O-ILD, n = 475) pattern. Patients included were mainly males (54%) with a mean age of 62 years. Results Patients with O-ILD exhibited a characteristic functional profile with reduced percent predicted forced expired volume in 1 s (FEV1) [65% (53–77) vs 83% (71–96), p