학술논문
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis
Document Type
article
Author
Torben Mentrup; Anna Yamina Stumpff-Niggemann; Nadja Leinung; Christine Schlosser; Katja Schubert; Rebekka Wehner; Antje Tunger; Valentin Schatz; Patrick Neubert; Ann-Christine Gradtke; Janina Wolf; Stefan Rose-John; Paul Saftig; Alexander Dalpke; Jonathan Jantsch; Marc Schmitz; Regina Fluhrer; Ilse D. Jacobsen; Bernd Schröder
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Dectin-1 is a critical component of the innate sensing repertoire which is involved in pattern based recognition of fungal pathogens. Here the authors show that intramembrane proteolysis is involved in the regulation of the antifungal host response by termination of the phagosomal signalling of Dectin-1.