학술논문
Diagnostic accuracy of research criteria for prodromal frontotemporal dementia
Document Type
article
Author
Alberto Benussi; Enrico Premi; Mario Grassi; Antonella Alberici; Valentina Cantoni; Stefano Gazzina; Silvana Archetti; Roberto Gasparotti; Giorgio G. Fumagalli; Arabella Bouzigues; Lucy L. Russell; Kiran Samra; David M. Cash; Martina Bocchetta; Emily G. Todd; Rhian S. Convery; Imogen Swift; Aitana Sogorb-Esteve; Carolin Heller; John C. van Swieten; Lize C. Jiskoot; Harro Seelaar; Raquel Sanchez-Valle; Fermin Moreno; Robert Jr. Laforce; Caroline Graff; Matthis Synofzik; Daniela Galimberti; James B. Rowe; Mario Masellis; Maria Carmela Tartaglia; Elizabeth Finger; Rik Vandenberghe; Alexandre Mendonça; Pietro Tiraboschi; Chris R. Butler; Isabel Santana; Alexander Gerhard; Isabelle Le Ber; Florence Pasquier; Simon Ducharme; Johannes Levin; Sandro Sorbi; Markus Otto; Alessandro Padovani; Jonathan D. Rohrer; Barbara Borroni; Genetic Frontotemporal dementia Initiative (GENFI)
Source
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Subject
Language
English
ISSN
1758-9193
Abstract
Abstract Background The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls. Methods A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment. Results The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (p < 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (p < 0.001). The addition of both markers further increased the AUC to 0.90 (p < 0.001). Conclusions The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD.