학술논문
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
Document Type
article
Author
Xuling Chang; Resham L. Gurung; Ling Wang; Aizhen Jin; Zheng Li; Renwei Wang; Kenneth B. Beckman; Jennifer Adams-Haduch; Wee Yang Meah; Kar Seng Sim; Weng Khong Lim; Sonia Davila; Patrick Tan; Jing Xian Teo; Khung Keong Yeo; Yiamunaa M.; Sylvia Liu; Su Chi Lim; Jianjun Liu; Rob M. van Dam; Yechiel Friedlander; Woon-Puay Koh; Jian-Min Yuan; Chiea Chuen Khor; Chew-Kiat Heng; Rajkumar Dorajoo
Source
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Xuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leukocyte telomere length and report a mechanistic pathway linking TERF1, leukocyte telomere length and incident colon cancer.