학술논문
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Document Type
article
Author
Giuseppe Deganutti; Yi-Lynn Liang; Xin Zhang; Maryam Khoshouei; Lachlan Clydesdale; Matthew J. Belousoff; Hari Venugopal; Tin T. Truong; Alisa Glukhova; Andrew N. Keller; Karen J. Gregory; Katie Leach; Arthur Christopoulos; Radostin Danev; Christopher A. Reynolds; Peishen Zhao; Patrick M. Sexton; Denise Wootten
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The glucagon-like peptide-1 receptor (GLP-1R) can be targeted in the treatment of diabetes, obesity and other metabolic disorders. Here, the authors assess the molecular mechanisms of peptide agonists binding to GLP-1R and the responses elucidated by these ligands, including distinct kinetics of G protein activation.