학술논문
Vasculogenic mimicry in small cell lung cancer
Document Type
article
Author
Stuart C. Williamson; Robert L. Metcalf; Francesca Trapani; Sumitra Mohan; Jenny Antonello; Benjamin Abbott; Hui Sun Leong; Christopher P. E. Chester; Nicole Simms; Radoslaw Polanski; Daisuke Nonaka; Lynsey Priest; Alberto Fusi; Fredrika Carlsson; Anders Carlsson; Mary J. C. Hendrix; Richard E. B. Seftor; Elisabeth A. Seftor; Dominic G. Rothwell; Andrew Hughes; James Hicks; Crispin Miller; Peter Kuhn; Ged Brady; Kathryn L. Simpson; Fiona H. Blackhall; Caroline Dive
Source
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is associated with worse overall survival, and alters tumour growth, chemotherapy delivery and efficacy.