학술논문
Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
Document Type
article
Author
Maud Voisin; Elina Shrestha; Claire Rollet; Cyrus A. Nikain; Tatjana Josefs; Mélanie Mahé; Tessa J. Barrett; Hye Rim Chang; Rachel Ruoff; Jeffrey A. Schneider; Michela L. Garabedian; Chris Zoumadakis; Chi Yun; Bara Badwan; Emily J. Brown; Adam C. Mar; Robert J. Schneider; Ira J. Goldberg; Inés Pineda-Torra; Edward A. Fisher; Michael J. Garabedian
Source
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Voisin et al. show that reducing phosphorylation at serine 196 of LXRα (LXRα pS196) in hematopoietic cells attenuates atherosclerosis and obesity of mice fed a high-fat diet. They find that the transcriptional activity of LXRα is reprogrammed in macrophages and T cells to promote an anti-inflammatory phenotype, thus identifying a functional role of LXRα pS196 in immune cells.