학술논문
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
Document Type
article
Author
Alison E. John; Rebecca H. Graves; K. Tao Pun; Giovanni Vitulli; Ellen J. Forty; Paul F. Mercer; Josie L. Morrell; John W. Barrett; Rebecca F. Rogers; Maryam Hafeji; Lloyd I. Bibby; Elaine Gower; Valerie S. Morrison; Yim Man; James A. Roper; Jeni C. Luckett; Lee A. Borthwick; Ben S. Barksby; Rachel A. Burgoyne; Rory Barnes; Joelle Le; David J. Flint; Susan Pyne; Anthony Habgood; Louise A. Organ; Chitra Joseph; Rochelle C. Edwards-Pritchard; Toby M. Maher; Andrew J. Fisher; Natasja Stæhr Gudmann; Diana J. Leeming; Rachel C. Chambers; Pauline T. Lukey; Richard P. Marshall; Simon J. F. Macdonald; R. Gisli Jenkins; Robert J. Slack
Source
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human and murine models of lung fibrosis via αvβ6 degradation.