학술논문
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis
Document Type
article
Author
Source
Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 4, Pp 415-420
Subject
Language
English
ISSN
1678-9849
0037-8682
0037-8682
Abstract
Abstract Pseudomonas aeruginosa is the leading cause of nosocomial infections with high mortality rates owing to the limited therapeutic options for multidrug-resistant Pseudomonas aeruginosa (MDRPA) and metallo-beta-lactamase (MBL)-producing strains. Herein, we present a meta-analysis exploring the association between MDRPA and São Paulo MBL-1 (SPM-1)-producing strains vs. mortality. Online databases were screened to identify studies published between 2006 and 2016. A total of 15 studies, comprising 3,201 cases of P. aeruginosa infection, were included. Our results demonstrated a higher mortality rate among patients infected with MDRPA (44.6%, 363/813) than those with non-MDRPA infection (24.8%, 593/2,388) [odds ratio (OR) 2.39, 95% confidence interval (CI) 1.70-3.36, p