학술논문
Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease
Document Type
article
Author
Source
Parkinson's Disease, Vol 2017 (2017)
Subject
Language
English
ISSN
2090-8083
2042-0080
2042-0080
Abstract
The genetic basis of festination, a common motor symptom in Parkinson’s disease (PD), remains unclear. Since polymorphism in the alpha-synuclein (SNCA) gene is associated with PD phenotype, we examined whether such polymorphism is also associated with festination. SNCA polymorphisms rs11931074 and rs894278 were genotyped in a consecutive series of 258 patients with PD, of whom 122 (47.3%) suffered festination. Univariate analysis revealed significant differences in genotype and minor allele frequencies at rs11931074 or rs894278 between patients with festination and those without it (all p