학술논문
Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
Document Type
article
Author
Source
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Resolution of granulomas in mycobacterial infection requires macrophages to switch from cytokine to nitric oxide (NO) production. Here the authors show that Mincle stimulates translation of the key NO synthesis genes by a mechanism dependent on p38-mediated hypusination of eiF5A.