학술논문
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
LRIG1 is a tumour suppressor in several cancers. Here, the authors show that androgen receptor directly transactivates LRIG1 which then antagonises ERBB signalling and c-Myc expression to inhibit prostate tumorigenesis.