학술논문
CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma
Document Type
article
Author
Feng Wang; Fen Zhao; Li Zhang; Lai Xiong; Qing Mao; Yanhui Liu; Xiaoguang Qiu; Xiang Wang; Lin Shui; Xi Chen; Kexing Ren; Pixian Shui; Qiongwen Zhang; Yifei Deng; Weimin Li; Xiaoqi Xie; Dengbin Wu; Tao Li; Jinyi Lang; Lei Liu; Huaying Chen; Jianguo Xu; Sen Bai; Zhiping Li; Qiang Yue; Ni Chen; Bingwen Zhou; Cheng Yi; Yuquan Wei; Yuchuan Fu; Yong Luo; Qiheng Gou; Lunxu Liu; Yuanzhao Liu; Jingbo Kang; Junjie Wang; Dongcun Jing; Fuquan Zhang; Xiaoyan Yang; Xianfeng Li; Tao Jiang; Zongcun Zhang; Yizhi Zhou; Junlin Yi
Source
Molecular Cancer, Vol 21, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
1476-4598
Abstract
Abstract Background Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors. However, it’s role in glioma, which is ranked as one of the common primary malignant tumor in the central nervous system and is associated with high morbidity and mortality, is unclear. Methods In this study, we explored CDC6 gene expression level in pan-cancer. Furthermore, we focused on the relationships between CDC6 expression, its prognostic value, potential biological functions, and immune infiltrates in glioma patients. We also performed vitro experiments to assess the effect of CDC6 expression on proliferative, apoptotic, migrant and invasive abilities of glioma cells. Results As a result, CDC6 expression was upregulated in multiple types of cancer, including glioma. Moreover, high expression of CDC6 was significantly associated with age, IDH status, 1p/19q codeletion status, WHO grade and histological type in glioma (all p