학술논문
Ankle Brachial Index and Subsequent Cardiovascular Disease Risk in Patients With Chronic Kidney Disease
Document Type
article
Author
Jing Chen; Emile R. Mohler; Pranav S. Garimella; L. Lee Hamm; Dawei Xie; Stephen Kimmel; Raymond R. Townsend; Matthew Budoff; Qiang Pan; Lisa Nessel; Susan Steigerwalt; Jackson T. Wright; Jiang He; Lawrence J. Appel; Harold I. Feldman; Alan S. Go; John W. Kusek; James P. Lash; Akinlolu Ojo; Mahboob Rahman
Source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 6 (2016)
Subject
Language
English
ISSN
2047-9980
Abstract
BackgroundThe clinical implications of ankle‐brachial index (ABI) cutpoints are not well defined in patients with chronic kidney disease (CKD) despite increased prevalence of high ABI attributed to arterial stiffness. We examined the relationship of ABI with cardiovascular disease (CVD) and all‐cause mortality among CKD patients. Methods and ResultsThree thousand six hundred twenty‐seven participants without clinical peripheral artery disease (PAD) at baseline from the Chronic Renal Insufficiency Cohort Study were included. ABI was obtained per standard protocol and CVD events were confirmed by medical record adjudication. A U‐shaped association of ABI with PAD, myocardial infarction (MI), composite CVD, and all‐cause mortality was observed. Individuals with an ABI between 1.0 and