학술논문
Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1
Document Type
article
Author
Prameladevi Chinnasamy; Isabel Casimiro; Dario F. Riascos-Bernal; Shreeganesh Venkatesh; Dippal Parikh; Alishba Maira; Aparna Srinivasan; Wei Zheng; Elena Tarabra; Haihong Zong; Smitha Jayakumar; Venkatesh Jeganathan; Kith Pradan; Jose O. Aleman; Rajat Singh; Sayan Nandi; Jeffrey E. Pessin; Nicholas E. S. Sibinga
Source
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Macrophages have been reported to regulate thermogenic, sympathetic neuron-mediated norepinephrine signaling in adipose tissues. Here the authors report that male mice lacking the allograft inflammatory factor-1 protein are resistant to diet-induced obesity, in association with higher adipose norepinephrine levels and lower expression of the norepinephrine catabolic enzyme monoamine oxidase A.