학술논문
Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas
Document Type
article
Author
Odessica Hughes; Amy R. Bentley; Charles E. Breeze; Francois Aguet; Xiaoguang Xu; Girish Nadkarni; Quan Sun; Bridget M. Lin; Thomas Gilliland; Mariah C. Meyer; Jiawen Du; Laura M. Raffield; Holly Kramer; Robert W. Morton; Mateus H. Gouveia; Elizabeth G. Atkinson; Adan Valladares-Salgado; Niels Wacher-Rodarte; Nicole D. Dueker; Xiuqing Guo; Yang Hai; Adebowale Adeyemo; Lyle G. Best; Jianwen Cai; Guanjie Chen; Michael Chong; Ayo Doumatey; James Eales; Mark O. Goodarzi; Eli Ipp; Marguerite Ryan Irvin; Minzhi Jiang; Alana C. Jones; Charles Kooperberg; Jose E. Krieger; Ethan M. Lange; Matthew B. Lanktree; James P. Lash; Paulo A. Lotufo; Ruth J.F. Loos; Vy Thi Ha My; Jesús Peralta-Romero; Lihong Qi; Leslie J. Raffel; Stephen S. Rich; Erik J. Rodriquez; Eduardo Tarazona-Santos; Kent D. Taylor; Jason G. Umans; Jia Wen; Bessie A. Young; Zhi Yu; Ying Zhang; Yii-Der Ida Chen; Tanja Rundek; Jerome I. Rotter; Miguel Cruz; Myriam Fornage; Maria Fernanda Lima-Costa; Alexandre C. Pereira; Guillaume Paré; Pradeep Natarajan; Shelley A. Cole; April P. Carson; Leslie A. Lange; Yun Li; Eliseo J. Perez-Stable; Ron Do; Fadi J. Charchar; Maciej Tomaszewski; Josyf C. Mychaleckyj; Charles Rotimi; Andrew P. Morris; Nora Franceschini
Source
Cell Genomics, Vol 4, Iss 1, Pp 100468- (2024)
Subject
Language
English
ISSN
2666-979X
Abstract
Summary: Chronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under-represented in genome-wide association studies (GWASs) of kidney function. To address this bias, we conducted a large meta-analysis of GWASs of estimated glomerular filtration rate (eGFR) in 145,732 AFR and AMS individuals. We identified 41 loci at genome-wide significance (p