학술논문
Retroviral b‐Zip protein (HBZ) contributes to the release of soluble and exosomal immune checkpoint molecules in the context of neuroinflammation
Document Type
article
Author
Source
Journal of Extracellular Biology, Vol 2, Iss 7, Pp n/a-n/a (2023)
Subject
Language
English
ISSN
2768-2811
Abstract
Abstract HTLV‐I‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive, neuroinflammatory demyelinating condition of the spinal cord. We have previously shown that aberrant expression and activity of immune checkpoint (ICP) molecules such as PD‐1 and PD‐L1/PD‐L2, negatively associates with the cytolytic potential of T cells in individuals with HAM/TSP. Interestingly, ICPs can exist in a soluble cell‐free form and can be carried on extracellular vesicles (EVs) and exosomes (small EVs,