학술논문
Local IL-17 Production Exerts a Protective Role in Murine Experimental Glomerulonephritis.
Document Type
article
Author
Source
PLoS ONE, Vol 10, Iss 8, p e0136238 (2015)
Subject
Language
English
ISSN
1932-6203
Abstract
IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney. Bone marrow chimeras were created using wild-type and IL-17 deficient mice and nephrotoxic nephritis was induced. IL-17 deficient hosts transplanted with wild-type bone marrow had worse disease by all indices compared to wild-type to wild-type bone marrow transplants (serum urea p