학술논문
Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
Document Type
article
Author
Marco Heestermans; Clément Naudin; Reiner K. Mailer; Sandra Konrath; Kristin Klaetschke; Anne Jämsä; Maike Frye; Carsten Deppermann; Giordano Pula; Piotr Kuta; Manuel A. Friese; Mathias Gelderblom; Albert Sickmann; Roger J. S. Preston; Jerzy-Roch Nofer; Stefan Rose-John; Lynn M. Butler; Ophira Salomon; Evi X. Stavrou; Thomas Renné
Source
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.