학술논문
Low cholesterol level associated with severity and outcome of spontaneous intracerebral hemorrhage: Results from Taiwan Stroke Registry.
Document Type
article
Author
Yu-Wei Chen; Chen-Hua Li; Chih-Dong Yang; Chung-Hsiang Liu; Chih-Hung Chen; Jau-Jiuan Sheu; Shinn-Kuang Lin; An-Chih Chen; Ping-Kun Chen; Po-Lin Chen; Chung-Hsin Yeh; Jiunn-Rong Chen; Yu-Jen Hsiao; Ching-Huang Lin; Shih-Pin Hsu; Tsang-Shan Chen; Sheng-Feng Sung; Shih-Chieh Yu; Chih-Hsin Muo; Chi Pang Wen; Fung-Chang Sung; Jiann-Shing Jeng; Chung Y Hsu; Taiwan Stroke Registry Investigators
Source
PLoS ONE, Vol 12, Iss 4, p e0171379 (2017)
Subject
Language
English
ISSN
1932-6203
Abstract
The relationship between cholesterol level and hemorrhagic stroke is inconclusive. We hypothesized that low cholesterol levels may have association with intracerebral hemorrhage (ICH) severity at admission and 3-month outcomes. This study used data obtained from a multi-center stroke registry program in Taiwan. We categorized acute spontaneous ICH patients, based on their baseline levels of total cholesterol (TC) measured at admission, into 3 groups with 200 mg/dL of TC. We evaluated risk of having initial stroke severity, with National Institutes of Health Stroke Scale (NIHSS) >15 and unfavorable outcomes (modified Rankin Scale [mRS] score >2, 3-month mortality) after ICH by the TC group. A total of 2444 ICH patients (mean age 62.5±14.2 years; 64.2% men) were included in this study and 854 (34.9%) of them had baseline TC 15), with an adjusted odds ratio [aOR] of 1.80; 95% confidence interval [CI], 1.41-2.30), and 3-month mRS >2 (aOR, 1.41; 95% CI, 1.11-1.78) using patients with TC >200 mg/dL as reference. Those with TC >160 mg/dL and body mass index (BMI)