학술논문
Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry
Document Type
article
Author
Andrea Salzano; Roberta D’Assante; Massimo Iacoviello; Vincenzo Triggiani; Giuseppe Rengo; Francesco Cacciatore; Ciro Maiello; Giuseppe Limongelli; Daniele Masarone; Angela Sciacqua; Pasquale Perrone Filardi; Antonio Mancini; Maurizio Volterrani; Olga Vriz; Roberto Castello; Andrea Passantino; Michela Campo; Pietro A. Modesti; Alfredo De Giorgi; Michele Arcopinto; Paola Gargiulo; Maria Perticone; Annamaria Colao; Salvatore Milano; Agnese Garavaglia; Raffaele Napoli; Toru Suzuki; Eduardo Bossone; Alberto M. Marra; Antonio Cittadini; T.O.S.CA. Investigators
Source
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
1475-2840
Abstract
Abstract Background Findings from the T.O.S.CA. Registry recently reported that patients with concomitant chronic heart failure (CHF) and impairment of insulin axis (either insulin resistance—IR or diabetes mellitus—T2D) display increased morbidity and mortality. However, little information is available on the relative impact of IR and T2D on cardiac structure and function, cardiopulmonary performance, and their longitudinal changes in CHF. Methods Patients enrolled in the T.O.S.CA. Registry performed echocardiography and cardiopulmonary exercise test at baseline and at a patient-average follow-up of 36 months. Patients were divided into three groups based on the degree of insulin impairment: euglycemic without IR (EU), euglycemic with IR (IR), and T2D. Results Compared with EU and IR, T2D was associated with increased filling pressures (E/e′ratio: 15.9 ± 8.9, 12.0 ± 6.5, and 14.5 ± 8.1 respectively, p