학술논문
An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
Document Type
article
Author
Chang-Han Lee; Tae Hyun Kang; Ophélie Godon; Makiko Watanabe; George Delidakis; Caitlin M. Gillis; Delphine Sterlin; David Hardy; Michel Cogné; Lynn E. Macdonald; Andrew J. Murphy; Naxin Tu; Jiwon Lee; Jonathan R. McDaniel; Emily Makowski; Peter M. Tessier; Aaron S. Meyer; Pierre Bruhns; George Georgiou
Source
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitulate the key processes for antibody persistence in circulation.