학술논문
Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice
Document Type
article
Author
Eva Conde; Romain Bertrand; Bianca Balbino; Jonathan Bonnefoy; Julien Stackowicz; Noémie Caillot; Fabien Colaone; Samir Hamdi; Raïssa Houmadi; Alexia Loste; Jasper B. J. Kamphuis; François Huetz; Laurent Guilleminault; Nicolas Gaudenzio; Aurélie Mougel; David Hardy; John N. Snouwaert; Beverly H. Koller; Vincent Serra; Pierre Bruhns; Géraldine Grouard-Vogel; Laurent L. Reber
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor. Here the authors show, in humanized mouse models, that dual vaccination against IL-4 and IL-13 induces their durable suppression ameliorate experimental asthma, and to hint clinical translation.