학술논문
Characterisation of airway disease associated with Sjögren disease
Document Type
article
Author
Eric Hachulla; Xavier Mariette; Jacques-Eric Gottenberg; Marie-Pierre Debray; Philippe Dieude; Alain Saraux; Olivier Vittecoq; Emanuelle Dernis; Raphaele Seror; Gaetane Nocturne; Cindy Marques; Veronique Le Guern; Claire Larroche; Robin Dhote; Pierre-Antoine Juge; Anne Laure Fauchais; Antoine Beurnier; Loïc Meudec
Source
RMD Open, Vol 10, Iss 1 (2024)
Subject
Language
English
ISSN
2056-5933
Abstract
Objective Although airway disease associated with Sjögren’s disease (Sjo-AD) is common, it is poorly studied compared with interstitial lung disease (ILD). In this study, we aimed to assess factors associated with Sjo-AD, the characteristics and prognosis of this manifestation.Methods We performed a retrospective multicentric study involving nine centres. We included Sjo-AD patients confirmed by at least one clinician and one CT scan report. Clinical and biological data, pulmonary function test (PFT), and CT scans were collected. A single radiologist specialist in thoracic diseases reviewed CT scans. Sjo-AD patients were compared with Sjo controls without pulmonary involvement, randomly selected after matching for age and disease duration.Results We included 31 Sjo-AD and 62 Sjo controls without pulmonary history. Sjo-AD had a higher disease activity (ESSDAI) compared with controls, even when excluding the pulmonary domain of the score (7 vs 3.8, p