학술논문
Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant
Document Type
article
Author
Simon Fiesack; Anne Smits; Maissa Rayyan; Karel Allegaert; Philippe Alliet; Wim Arts; An Bael; Luc Cornette; Ann De Guchtenaere; Nele De Mulder; Isabel George; Elisabeth Henrion; Kirsten Keiren; Nathalie Kreins; Marc Raes; Pierre Philippet; Bart Van Overmeire; Myriam Van Winckel; Vinciane Vlieghe; Yvan Vandenplas; on behalf of the Groups
Source
Nutrients, Vol 13, Iss 11, p 4109 (2021)
Subject
Language
English
ISSN
2072-6643
Abstract
Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB incidence. Simultaneously, information on practices was collected from Belgian pediatric and neonatal departments. Based on the review and these practices, a consensus was developed and voted on by all co-authors and heads of pediatric departments. Today, practices vary. In line with literature, the advised prophylactic regimen is 1 or 2 mg IM vitamin K once at birth. In the case of parental refusal, healthcare providers should inform parents of the slightly inferior alternative (2 mg oral vitamin K at birth, followed by 1 or 2 mg oral weekly for 3 months when breastfed). We recommend 1 mg IM in preterm