학술논문
The A4 study: β‐amyloid and cognition in 4432 cognitively unimpaired adults
Document Type
article
Source
Annals of Clinical and Translational Neurology, Vol 7, Iss 5, Pp 776-785 (2020)
Subject
Language
English
ISSN
2328-9503
Abstract
Abstract Objective To clarify the preclinical stage of Alzheimer’s disease by estimating when β‐amyloid accumulation first becomes associated with changes in cognition. Methods Here we studied a large group (N = 4432) of cognitively unimpaired individuals who were screened for inclusion in the A4 trial (age 65–85) to assess the effect of subthreshold levels of β‐amyloid on cognition and to identify which cognitive domains first become affected. Results β‐amyloid accumulation was linked to significant cognitive dysfunction in cognitively unimpaired participants with subthreshold levels of β‐amyloid in multiple measures of memory (Logical Memory Delayed Recall, P = 0.03; Free and Cued Selective Reminding Test, P