학술논문
The role of hormones in the differences in the incidence of breast cancer between Mongolia and the United Kingdom.
Document Type
article
Author
Source
PLoS ONE, Vol 9, Iss 12, p e114455 (2014)
Subject
Language
English
ISSN
1932-6203
Abstract
BACKGROUND:There are striking differences in breast cancer incidence between Asian and western women. Rates vary substantially within Asia also, with Mongolia's even lower than China's. These profound differences have been speculated to be due in part to diet, mediated by circulating hormone concentrations. METHODS:Sex steroid hormone concentrations were measured in women living in Ulaanbaatar, Mongolia and the United Kingdom (U.K.). Diet was obtained by interview and national survey data. Mean hormone differences were compared by country, and systematic variation by number of days since last menstrual period was modeled and adjusted for age and parity; difference in overall area under the curves was assessed. FINDINGS:The diet in Mongolia was higher in meat and dairy than in the U.K. Mean testosterone concentrations were 18.5% lower (p