학술논문
Effects of lifestyle and associated diseases on serum CC16 suggest complex interactions among metabolism, heart and lungs
Document Type
article
Author
Nathalie Rohmann; Paula Stürmer; Corinna Geisler; Kristina Schlicht; Carina Knappe; Katharina Hartmann; Kathrin Türk; Tim Hollstein; Alexia Beckmann; Anna K. Seoudy; Ulla Becker; Perdita Wietzke-Braun; Ute Settgast; Florian Tran; Philip Rosenstiel; Jan H. Beckmann; Witigo von Schönfels; Stephan Seifert; Jan Heyckendorf; Andre Franke; Stefan Schreiber; Dominik M. Schulte; Matthias Laudes
Source
Journal of Advanced Research, Vol 59, Iss , Pp 161-171 (2024)
Subject
Language
English
ISSN
2090-1232
Abstract
Introduction: Clara cell 16-kDa protein (CC16) is an anti-inflammatory, immunomodulatory secreted pulmonary protein with reduced serum concentrations in obesity according to recent data. Objective: Studies focused solely on bodyweight, which does not properly reflect obesity-associated implications of the metabolic and reno-cardio-vascular system. The purpose of this study was therefore to examine CC16 in a broad physiological context considering cardio-metabolic comorbidities of primary pulmonary diseases. Methods: CC16 was quantified in serum samples in a subset of the FoCus (N = 497) and two weight loss intervention cohorts (N = 99) using ELISA. Correlation and general linear regression analyses were applied to assess CC16 effects of lifestyle, gut microbiota, disease occurrence and treatment strategies. Importance and intercorrelation of determinants were validated using random forest algorithms. Results: CC16 A38G gene mutation, smoking and low microbial diversity significantly decreased CC16. Pre-menopausal female displayed lower CC16 compared to post-menopausal female and male participants. Biological age and uricosuric medications increased CC16 (all p