학술논문
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
Document Type
article
Author
Philip J. M. Brouwer; Aleksandar Antanasijevic; Zachary Berndsen; Anila Yasmeen; Brooke Fiala; Tom P. L. Bijl; Ilja Bontjer; Jacob B. Bale; William Sheffler; Joel D. Allen; Anna Schorcht; Judith A. Burger; Miguel Camacho; Daniel Ellis; Christopher A. Cottrell; Anna-Janina Behrens; Marco Catalano; Iván del Moral-Sánchez; Thomas J. Ketas; Celia LaBranche; Marit J. van Gils; Kwinten Sliepen; Lance J. Stewart; Max Crispin; David C. Montefiori; David Baker; John P. Moore; Per Johan Klasse; Andrew B. Ward; Neil P. King; Rogier W. Sanders
Source
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine immunogenicity in a small animal model.