학술논문
Plasma elaidic acid level as biomarker of industrial trans fatty acids and risk of weight change: report from the EPIC study.
Document Type
article
Author
Véronique Chajès; Carine Biessy; Pietro Ferrari; Isabelle Romieu; Heinz Freisling; Inge Huybrechts; Augustin Scalbert; Bas Bueno de Mesquita; Dora Romaguera; Marc J Gunter; Paolo Vineis; Camilla Plambeck Hansen; Marianne Uhre Jakobsen; Françoise Clavel-Chapelon; Guy Fagherazzi; Marie-Christine Boutron-Ruault; Verana Katzke; Jasmine Neamat-Allah; Heiner Boeing; Ursula Bachlechner; Antonia Trichopoulou; Androniki Naska; Philippos Orfanos; Valeria Pala; Giovanna Masala; Amalia Mattiello; Guri Skeie; Elisabete Weiderpass; Antonio Agudo; Jose Maria Huerta; Eva Ardanaz; Maria Jose Sánchez; Miren Dorronsoro; Jose Ramon Quirós; Ingegerd Johansson; Anna Winkvist; Emily Sonested; Tim Key; Kay-Tee Khaw; Nicolas J Wareham; Petra H M Peeters; Nadia Slimani
Source
PLoS ONE, Vol 10, Iss 2, p e0118206 (2015)
Subject
Language
English
ISSN
1932-6203
Abstract
BACKGROUND:Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS:Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow-up, age, energy, alcohol, smoking status, physical activity, and region. RESULTS:In women, doubling elaidic acid was associated with a decreased risk of weight loss (odds ratio (OR) = 0.69, 95% confidence interval (CI) = 0.55-0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5-year follow-up (OR = 1.23, 95% CI = 0.97-1.56, p = 0.082) (p-trend