학술논문
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Document Type
article
Author
Maximilian Wranik; Tobias Weinert; Chavdar Slavov; Tiziana Masini; Antonia Furrer; Natacha Gaillard; Dario Gioia; Marco Ferrarotti; Daniel James; Hannah Glover; Melissa Carrillo; Demet Kekilli; Robin Stipp; Petr Skopintsev; Steffen Brünle; Tobias Mühlethaler; John Beale; Dardan Gashi; Karol Nass; Dmitry Ozerov; Philip J. M. Johnson; Claudio Cirelli; Camila Bacellar; Markus Braun; Meitian Wang; Florian Dworkowski; Chris Milne; Andrea Cavalli; Josef Wachtveitl; Michel O. Steinmetz; Jörg Standfuss
Source
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitude in time.