학술논문
Clinical characteristics and outcomes in risk-stratified patients with smoldering multiple myeloma: data from the Czech Republic Registry of Monoclonal Gammopathies
Document Type
article
Author
Viera Sandecka; Tereza Popkova; Martin Stork; Vladimir Maisnar; Jiri Minarik; Alexandra Jungova; Petr Pavlicek; Lukas Stejskal; Lenka Pospisilova; Adriana Heindorfer; Jarmila Obernauerova; Evzen Gregora; Michal Sykora; Jana Ullrychova; Marek Wrobel; Petr Kessler; Tomas Jelinek; Peter Kunovszki; Sacheeta Bathija; Blanca Gros; Sabine Wilbertz; Qian Cai; Annette Lam; Ivan Spicka
Source
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-8 (2023)
Subject
Language
English
ISSN
2044-5385
Abstract
Abstract Smoldering multiple myeloma (SMM) is an asymptomatic precursor to active multiple myeloma (MM). The aim of this study was to report clinical characteristics and outcomes of patients with SMM stratified based on their risk of progression to MM using the Mayo 20/2/20 criteria. Data were leveraged from the Czech Myeloma Group Registry of Monoclonal Gammopathies (RMG). Key outcomes included progression-free survival from SMM diagnosis to active MM diagnosis or death (PFS), progression-free survival from SMM diagnosis to progression on first line (1 L) MM treatment or death (PFS2), and overall survival (OS). Of 498 patients, 174 (34.9%) were classified as high risk and 324 (65.1%) as non–high risk. Median follow-up was approximately 65 months. During follow-up, more patients in the high-risk vs non–high-risk group received 1 L MM treatment (76.4% vs 46.6%, p