학술논문
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
Document Type
article
Author
Niels Grote Beverborg; Daniela Später; Ralph Knöll; Alejandro Hidalgo; Steve T. Yeh; Zaher Elbeck; Herman H. W. Silljé; Tim R. Eijgenraam; Humam Siga; Magdalena Zurek; Malin Palmér; Susanne Pehrsson; Tamsin Albery; Nils Bomer; Martijn F. Hoes; Cornelis J. Boogerd; Michael Frisk; Eva van Rooij; Sagar Damle; William E. Louch; Qing-Dong Wang; Regina Fritsche-Danielson; Kenneth R. Chien; Kenny M. Hansson; Adam E. Mullick; Rudolf A. de Boer; Peter van der Meer
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ischemia-driven heart failure.