학술논문
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
Document Type
article
Author
Phyllis F. Cheung; JiaJin Yang; Rui Fang; Arianna Borgers; Kirsten Krengel; Anne Stoffel; Kristina Althoff; Chi Wai Yip; Elaine H. L. Siu; Linda W. C. Ng; Karl S. Lang; Lamin B. Cham; Daniel R. Engel; Camille Soun; Igor Cima; Björn Scheffler; Jana K. Striefler; Marianne Sinn; Marcus Bahra; Uwe Pelzer; Helmut Oettle; Peter Markus; Esther M. M. Smeets; Erik H. J. G. Aarntzen; Konstantinos Savvatakis; Sven-Thorsten Liffers; Smiths S. Lueong; Christian Neander; Anna Bazarna; Xin Zhang; Annette Paschen; Howard C. Crawford; Anthony W. H. Chan; Siu Tim Cheung; Jens T. Siveke
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation of MHC class I via autophagy.