학술논문
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
Document Type
article
Author
Raha Pazoki; Marijana Vujkovic; Joshua Elliott; Evangelos Evangelou; Dipender Gill; Mohsen Ghanbari; Peter J. van der Most; Rui Climaco Pinto; Matthias Wielscher; Matthias Farlik; Verena Zuber; Robert J. de Knegt; Harold Snieder; André G. Uitterlinden; Lifelines Cohort Study; Julie A. Lynch; Xiyun Jiang; Saredo Said; David E. Kaplan; Kyung Min Lee; Marina Serper; Rotonya M. Carr; Philip S. Tsao; Stephen R. Atkinson; Abbas Dehghan; Ioanna Tzoulaki; M. Arfan Ikram; Karl-Heinz Herzig; Marjo-Riitta Järvelin; Behrooz Z. Alizadeh; Christopher J. O’Donnell; Danish Saleheen; Benjamin F. Voight; Kyong-Mi Chang; Mark R. Thursz; Paul Elliott; the VA Million Veteran Program
Source
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Plasma levels of liver enzymes provide insights into hepatic function and related diseases. Here, the authors perform a genome-wide association study on three liver enzymes, identifying genetic variants associated with their plasma concentration as well as links to metabolic and cardiovascular diseases.