학술논문
Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Although genome-wide association studies have identified genetic variation contributing to disease risk, assigning causal genes is challenging. Here, the authors generate ATAC-seq, Hi-C, Capture Hi-C and RNA-seq data in stimulated CD4+ T cells to identify functional enhancers and demonstrate interactions of expression quantitative trait loci with target genes in rheumatoid arthritis.