학술논문
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
Document Type
article
Author
Stephen Watt; Louella Vasquez; Klaudia Walter; Alice L. Mann; Kousik Kundu; Lu Chen; Ying Sims; Simone Ecker; Frances Burden; Samantha Farrow; Ben Farr; Valentina Iotchkova; Heather Elding; Daniel Mead; Manuel Tardaguila; Hannes Ponstingl; David Richardson; Avik Datta; Paul Flicek; Laura Clarke; Kate Downes; Tomi Pastinen; Peter Fraser; Mattia Frontini; Biola-Maria Javierre; Mikhail Spivakov; Nicole Soranzo
Source
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
PU.1 is a master regulator of myeloid development but its role in disease-relevant neutrophils is not well known. Here, the authors look at primary neutrophils from a human population and find that genetic variants affecting binding of PU.1 are associated with cell count and disease susceptibility.