학술논문
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract
Document Type
article
Author
Ekaterina Yonova-Doing; Wanting Zhao; Robert P. Igo; Chaolong Wang; Periasamy Sundaresan; Kristine E. Lee; Gyungah R. Jun; Alexessander Couto Alves; Xiaoran Chai; Anita S. Y. Chan; Mei Chin Lee; Allan Fong; Ava G. Tan; Chiea Chuen Khor; Emily Y. Chew; Pirro G. Hysi; Qiao Fan; Jacqueline Chua; Jaeyoon Chung; Jiemin Liao; Johanna M. Colijn; Kathryn P. Burdon; Lars G. Fritsche; Maria K. Swift; Maryam H. Hilmy; Miao Ling Chee; Milly Tedja; Pieter W. M. Bonnemaijer; Preeti Gupta; Queenie S. Tan; Zheng Li; Eranga N. Vithana; Ravilla D. Ravindran; Soon-Phaik Chee; Yuan Shi; Wenting Liu; Xinyi Su; Xueling Sim; Yang Shen; Ya Xing Wang; Hengtong Li; Yih-Chung Tham; Yik Ying Teo; Tin Aung; Kerrin S. Small; Paul Mitchell; Jost B. Jonas; Tien Yin Wong; Astrid E. Fletcher; Caroline C. W. Klaver; Barbara E. K. Klein; Jie Jin Wang; Sudha K. Iyengar; Christopher J. Hammond; Ching-Yu Cheng
Source
Communications Biology, Vol 3, Iss 1, Pp 1-8 (2020)
Subject
Language
English
ISSN
2399-3642
Abstract
Here, the authors report a multi-ethnic genome wide association meta-analysis of 12 studies from the International Cataract Genetics Consortium. They find six new loci associated with age-related nuclear cataract, in addition to replicating the association at CRYAA, and suggest a strong genetic link between age-related nuclear and congenital cataracts.