학술논문
A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts
Document Type
article
Author
Jessica D. Gereige; Hanfei Xu; Victor E. Ortega; Michael H. Cho; Ming Liu; Phuwanat Sakornsakolpat; Edwin K. Silverman; Terri H. Beaty; Bruce E. Miller; Per Bakke; Amund Gulsvik; Craig P. Hersh; Jarrett D. Morrow; Elizabeth J. Ampleford; Gregory A. Hawkins; Eugene R. Bleecker; Deborah A. Meyers; Stephen P. Peters; Juan C. Celedón; Kelan Tantisira; Jiang Li; Josée Dupuis; George T. O'Connor
Source
ERJ Open Research, Vol 8, Iss 2 (2022)
Subject
Language
English
ISSN
2312-0541
23120541
23120541
Abstract
Introduction Bronchodilator response (BDR) is a measurement of acute bronchodilation in response to short-acting β2-agonists, with a heritability between 10 and 40%. Identifying genetic variants associated with BDR may lead to a better understanding of its complex pathophysiology. Methods We performed a genome-wide association study (GWAS) of BDR in six adult cohorts with participants of European ancestry (EA) and African ancestry (AA) including community cohorts and cohorts ascertained on the basis of obstructive pulmonary disease. Validation analysis was carried out in two paediatric asthma cohorts. Results A total of 10 623 EA and 3597 AA participants were included in the analyses. No single nucleotide polymorphism (SNP) was associated with BDR at the conventional genome-wide significance threshold (p