학술논문
Urinary soluble VCAM-1 is a useful biomarker of disease activity and treatment response in lupus nephritis
Document Type
article
Author
Source
BMC Rheumatology, Vol 4, Iss 1, Pp 1-10 (2020)
Subject
Language
English
ISSN
2520-1026
Abstract
Abstract Introduction Vascular cell adhesion molecule-1 (VCAM-1) is involved in the progression of glomerular and tubulointerstitial injury in lupus nephritis (LN) and can be easily assessed in urine. The aim of this study was to assess urinary soluble VCAM-1 (uVCAM-1) as a biomarker of disease activity and treatment response in LN. Methods This prospective study enrolled 62 patients with class III, IV or V LN diagnosed within the last 3 years and divided them in two groups: with and without active nephritis at the inclusion, each group with 31 patients. At each visit, a urine sample was collected for uVCAM-1 evaluation and the nephritis status was assessed. Results Median uVCAM-1 level was elevated in patients with active compared to inactive LN (P